Women with a uterus, those who have NOT undergone a hysterectomy (removal of the womb) who are on estrogen also need to be on progesterone. This is to protect against endometrial or uterine cancer.

Alzheimer's disease

Background | Links| Herbs


BACKGROUND


Since ancient times people were aware that aging could bring memory loss and that some of their elders faced the sad prospect of "senility" or "second childhood." Only in the past 20 years has Alzheimer's disease, the condition chiefly responsible for this outcome, became recognized as a defined illness.
The exact causes of Alzheimer's disease are still not known and there is still no cure, but much progress has been made in understanding how information is stored in the brain and where breakdowns occur. An estimated 4 million Americans now have Alzheimer's disease, with as many as one in three families affected.
Estrogen enhances memory. This has been shown in several studies. Estrogen deficiency is associated with memory loss whether medically induced or natural. Postmenopausal women often suffer from memory loss.
The first study showing estrogen could improve memory loss in women was undertaken in 1954. Studies now underway are showing HRT can significantly improve functioning in postmenopausal women diagnosed with Alzheimer's Disease. Postmenopausal women who receive HRT are 40-60% less likely to develop Alzheimer's Disease!
The available data is encouraging in that estrogen can prevent and treat Alzheimer's Disease in postmenopausal women.


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The Herbal Connection


Over the years several herbs have reportedly been useful in improving memory in old age. Ginkgo biloba, Hawthorne berries, and sage are the three most commonly mentioned. Sage is steeped in legend it is reported that the Chinese would trade three chests of their finest tea for one of sage. To bring you up to date, sage oil is now being studied by researchers in Great Britain for it's possible use in Alzheimer's. Much more research has been done on Ginkgo Biloba. Over 50 scientific studies have been done in Europe on the use of ginkgo for dementia.

Ginkgo biloba has recently been approved in Germany for the treatment of Alzheimer's disease. Last October a study published in the Journal of the American Medical Association showed that extracts of ginko biloba can stabilize and, in a substantial number of cases, improve mental performance and social functioning for 6 months to 1 year. JAMA 1997 ; 278 : 1327-1332.

In another study published in The New England Journal of Medicine in April of 1997 Patients with moderately severe impairment from Alzheimer's disease, treatment with vitamin E slowed the progression of disease. N Engl J Med 1997 ; 336 : 1216-22.

The Herbs and Vitamins


GINKO BILOBA
( Ginko biloba )

Other Names: Maidenhair Tree, Bai Guo ( EGb 761 ).

General Description: The Ginko is one of the oldest tree species on earth. It is widely cultivated in America as an import from China.

Parts Used: The leaf.

Active Ingredients: ginkoflavonglycosides.

Traditional Uses: Ginko's use in China dates back to 2800B.C. It was mainly used for breathing difficulties and for it's beneficial effect on the brain.

Current Status: There have been more than 50 double-blind clinical trials showing Ginko's favorable effects on vascular insufficiency and age related decrease in brain function. Ginko may be useful for the forgetfulness many post menopausal women complain of. Some women are using Ginko in combination with Hawthorn for forgetfulness. Ginko may hold promise in the treatment of PMS as well.

Precautions: Ginko is non-toxic. But may have interactions with blood thinners.

References: 23, 24, 25, 26.


Vitamin E
(d-alpha tocopherol)

Food Sources: Polyunsaturated vegetable oil, seeds and nuts.

Adult Female ( RDA ): 12 International Units (IU).

Types Available: In natural vitamin E the small d in d-alpha tocopherol signifies a natural source which is preferable to synthetic vitamin E signified by the dl in dl-alpha tocopherol. Mixed tocopherols contain d-alpha, beta, delta and gamma tocopherols. Mixed tocopherols offer the greatest benefit. Look for natural mixed tocopherols.

Beneficial Effects: Vitamin E is an antioxidant. Can it prevent hot flashes? There were studies done in the late 1940's showing it to relieve hot flashes and postmenopausal vaginal dryness. More recent studies are lacking. There are other benefits. We know from the Nurses Health Study that women who took vitamin E over a two-year period reduced their risk of fatal heart attacks by 40%. Vitamin E is also being studied for its effect on Alzheimer's disease and cancer. Combining vitamin E with other anti oxidants such as selenium, chromium, beta-carotene, and vitamin C may offer a synergistic effect. That means they work better together than separate.

Dosage: 400-1200 IU a day.

Precautions: Vitamin E potentiate (cause a greater effect) of anticoagulant drugs such as Coumadin or aspirin. If you are on either of these drugs consult your doctor before starting vitamin E.

References : 87, 88, 89, 90, 91. .

HAWTHORN
(Crataegus oxyacantha)

Other Names: Crataegs monogyna Mayflower, May Bush, English Hawthorn.

General Description: A thorny European tree with bright red berries, grows to 25 feet tall.

Parts Used: The berries and flowers

Active Ingredients: vitexin-2"rhamnoside

Traditional Uses: Known since the Middle Ages, used in China, Europe and America for heart and circulatory disorders.

Current Status: Hawthorn dilates blood vessels and improves circulation. Has been used in combination with Ginko biloba to improve post menopausal memory loss. Studies of it's effectiveness in this area are lacking.

Precautions: Self treatment for heart disease is a bad idea. If you have or suspect that you have heart disease you need to consult a health care professional.

References: 1, 15, 16.

Disclaimer - Menopause-Online is not intended as medical advice. Its intent is solely informational and educational. The information is not a substitute for talking with your health professional.

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